Electrodiagnostic profile of conduction slowing in amyotrophic lateral sclerosis

ObjectiveSince motor nerve conduction slowing can occur due to loss of large axons, we investigate the profile in ALS and identify limits beyond which diagnosis exclusive axonal is unlikely.MethodsFirst, using linear regression analysis, established range 76 CIDP patients. Demyelinating confidence intervals were defined by assessing velocity (CV), distal latency (DML), F-wave (F) relation compound muscle action potential (CMAP) amplitude median, ulnar, fibular, tibial nerves. Results subsequently validated 38 additional Then, newly demyelination used 95 patients.ResultsCV slowing, prolonged DML, abnormal F observed 22.2%, 19.6%, 47.1% studied nerves respectively When occurred, it affected more than one segment nerve, suggesting that CMAP dependent caused an axons main mechanism slowing. No patient had 2 with CV interval equations or American Academy Neurology (AAN) research criteria for diagnosis.ConclusionsThe presence two demyelinating analysis AAN patients suggests contribution acquired other mechanisms exist electrodiagnostic ALS.